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KMID : 0352120140290010067
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Journal of Kyung Hee University
2014 Volume.29 No. 1 p.67 ~ p.71
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The Effect of Nitrous Oxide in General Anesthesia
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Shin Dong-Wook
Chung Kum-Hee
Lee Ju-Ho
Park Soo-Yeun
Ahn So-Woon
Chun Duk-Hee
Yang Hyeon-Jeong
Kang Hwa-Ja
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Abstract
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Objectives: Theoretically, the administration of nitrous oxide (N2O) may reduces the doses of other anesthetics used. This study was performed to evaluate the influences of N2O to other anesthetics used.
Methods: In this study, 104 gynecologic patients aged 18-60 years undergoing elective surgery were investigated. Anesthesia was induced with using propofol 2 mg/kg, vecuronium bromide 0.1 mg/kg and remifentanil 2 ug/kg. In group 1 (G1), anesthesia was maintained with N2O/O2 (50%/50%), sevoflurane 2.0 vol% and infusion of remifentanil 0.2 ug/kg/min. In group 2 (G2), anesthesia was maintained with Air/O2 (50%/50%), sevoflurane 2.0 vol% and remifentanil infusion 0.2 ug/kg/min. Hemodynamic changes over 15% with Bispectral Index (BIS) score over 60 were controlled with sevoflurane and remifentanil. Ephedrine or antihypertensive drug is used in uncontrolled cases of blood pressure in spite of BIS score 40～60. The doses of sevoflurane, remifentanil, ephedrine, antihypertensives intraoperatively and the time of awakening were measured. In recovery room, recovery index, the doses of antiemetics and analgesics were measured.
Results: There was no significant difference between groups in doses of sevoflurane, ephedrine, antihypertensives and in emergency time. The recovery index, doses of antiemetics and analgesics used in postoperative phase were not different between groups.
Conclusion: This study demonstrates that remifentanil infusion may be substituted for N2O during sevoflurane anesthesia without any clinically significant changes in outcome.
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KEYWORD
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Nitrous oxide, Remifentanil, Sevoflurane
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